Now Hiring - Principal Technical Development Scientist (Genomics) in San Francisco, CA

The Position

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

Job Description:

This position is part of the Pharma Individualized Medicines Team in the Pharma Cell and Gene Therapy (PTC) organization responsible for the process development, manufacture and supply of individualized cell and gene therapies. Innovative therapies and strategic collaborations with our global CGT partners ensures growth opportunities that are uncommon in scale and scope to directly impact the delivery of truly transformational cell and gene therapies.

The PTC Genomics team is seeking a Principal Technical Development Scientist (Genomics) to lead development and implementation of cutting-edge genomic technologies supporting Roche’s diverse cell and gene therapy portfolio. The core technical team is composed of scientists working in a highly dynamic environment across a variety of clinical programs and core functions. The candidate is expected to collaborate extensively with Genentech Research and Early Development, Pharma Technical Development, Pharma Technical Cell and Gene Therapy, Regulatory, Quality and Manufacturing within Roche. The position would suit an individual with strong biological and computational capabilities and excellent communication and collaboration skills.

The Genomics Principal Technical Development Scientist’s responsibilities will include but are not limited to the following:

• Provide subject matter expertise in the design, verification and validation of a broad range of next-generation sequencing (NGS) based processes in alignment with product core strategy and milestones from Technical Development teams.

• Lead end to end development and optimization of new and existing NGS assays and processes that are ready for scale-up and automation, using cutting edge nucleic acid & library preparation and next generation sequencing using various sequencing platforms.

• Support authoring and review of genomics technical portions of regulatory submissions and provide technical support to quality teams for specific CGTs

• Write and review reports, technical documents and presentations to support NGS assay development, qualification, validation and transfer.

• Represent PTC Genomics to internal and external stakeholders including Research and Early Development, Pharma Technical Development and corporate partners

• Mentor and train junior scientists, interns or associates on technical projects

Required Qualifications:

• Ph.D. or equivalent advanced degree in the Life Sciences (genomics, molecular biology, systems biology, synthetic biology, biochemistry, and/or cancer biology)

• 5+ years of postdoctoral experience in applying genomic approaches to solve complex biological problems in pharma/biotech or clinical environments

• Deep experience in wet lab and dry lab environments in genomics applications and NGS technologies for analysis of DNA, RNA, protein including genome-wide, single-cell and targeted approaches like RNAseq, Whole-Genome, Whole-Exome Sequencing and ScRNAseq.

• Must have excellent communication and people skills to work collaboratively in a highly matrixed environment and clearly communicate across diverse audiences with a range of technical knowledge

• Self driven and comfortable with changing priorities and a fast paced environment.

Nice to have Qualifications:

• Experience with documentation requirements for genomics workflows in non-clinical vs clinical environments with CLIA-CAP other quality or regulatory requirements

• Substantial technical experience with analysis and interpretation of NGS data including but not limited to WES/WGS/RNAseq applications in cancer biology or immuno-oncology based cell and gene therapies

• Ability to work in a dynamic environment with multiple products and technologies

• Knowledge of scientific and engineering principles for drug development and cGMP requirements

Relocation benefits are approved for this posting.

The expected salary range for this position based on the primary location of South San Francisco, CA is $117,700 - $218,500.

Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.